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KMID : 0370220080520010027
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Yakhak Hoeji
2008 Volume.52 No. 1 p.27 ~ p.32
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Modulation of Th1/Th2 Cytokine Secretion in Human Peripheral Blood Mononuclear Cells by Water Extract of Acanthopanax divaricatus var. albeofructus Fruits
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Lyu Su-Yun
Noh Bin-Na
Park Won-Bong
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Abstract
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Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, IFN-? and TNF-α) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th-1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.
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KEYWORD
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Acanthopanax, Fruits, Immunomodulatory, Cytokine, Th-1/Th-2, ELISA
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